Whether your players are touching something they shouldn’t or falling prey to mad experiments, these mutations are sure to challenge their creativity. Transform your game with this list of one hundred unique mutations, ranging from grotesque deformities to uncanny abilities.
| d100 | Entry |
|---|---|
| 1 | Your very flesh is in a constant state of decay and regrowth. After three day's time, your skin completely rots off, giving way for a new batch of skin underneath. This process repeats itself indefinitely. |
| 2 | You become a weird hybrid between a human and a goat. Your feet become hooves, you sprout horns from your head, and hair grows all across your body. |
| 3 | Your skin begins to grow, but your body and organs stay the same size. Soon, you are covered in extra skin that you must carry around. |
| 4 | All the hair on your body shifts to the right side of your body, leaving your left side completely hairless. |
| 5 | A cloud of flies begins to form around you and follow you everywhere you go. The buzzing never stops, making it difficult to sleep. |
| 6 | Your skin becomes hard and bumpy all over. When you aren't wearing normal armor, you still use the AC for leather armor. |
| 7 | All the hair on your body begins to quickly fall out, leaving you completely hairless. |
| 8 | Your two eyes begin to migrate to the center of your forehead until you are a cyclops. |
| 9 | Your fingers begin to elongate to three times their normal length. |
| 10 | One of your arms (your dominant arm) begins to shrivel up and shrink in size. |
| 11 | Your knees begin to lock up and fuse in place. You can no longer bend your knees. |
| 12 | Your tongue begins to grow at an alarming rate, until it is close to a foot long. |
| 13 | Your skin becomes covered in painful boils that emit a nauseating odor. |
| 14 | You are all of a sudden infected with a horrible disease. Your skin is in a constant state of rot and decay, but you do not feel it. Anyone that you touch will catch the disease, and they WILL feel the pain. |
| 15 | You grow 1d4 flesh antlers out of your head. |
| 16 | A slow drip of blood begins to flow from your eyes at all times. |
| 17 | Your brain stretches beyond the normal limits of human comprehension, giving you the ability to move tiny objects with your mind through telekinesis. |
| 18 | Your skin becomes a jet black color with faint little white marks, resembling the night sky. |
| 19 | A group of tentacles begin to sprout out of your head in a circle forming a crown. |
| 20 | Your skin produces a metallic sheen. |
| 21 | A massive, writhing tumor appears in a random location on your body. As if that wasn't strange enough, it soon sprouts a mouth and begins whispering horrible things to you. |
| 22 | A large fatty hump begins to form on your upper back. |
| 23 | Your skin begins to emit a slight smoke. |
| 24 | Your body becomes much larger and bloated, giving you a horrifying bulging appearance. |
| 25 | Your vocal chords begin to shrink, preventing you from talking above a whisper. |
| 26 | Your skin becomes the consistency of dried leather, giving a cracking sound effect every time you bend an appendage. |
| 27 | Random teeth in your mouth begin to grow into painful fangs. |
| 28 | The spawn of some horrible nameless being begins to grow inside your belly. You can feel it move. |
| 29 | A vile ooze begins to slowly pour out of every single one of your orifices. Once per week, a living green ooze crawls out of you. |
| 30 | You suddenly have immense control over every single muscle in your face. With a thought, you can contort your face into that of any person you can imagine. It takes intense concentration for you to hold the facial disguise. |
| 31 | The hairs on your legs and arms harden and turn into bristles. |
| 32 | All the hair on your body begins to grow at a rapid rate. |
| 33 | Your body secretes a slippery oil that can be harvested and used as 1 flask of lamp oil a day. Your skin is incredibly flammable. |
| 34 | Your fingernails and toenails begin to grow at an alarming rate. Once cut, they will become uncomfortably long again within 1d4 hours. If left unattended, they will continue to grow and grow until you physically cannot go on. |
| 35 | You grow a massive mane of hair, like you would find on a lion. It is the same color as your natural hair color. |
| 36 | The muscles in your body have seemingly doubled in size. Add +1 to your strength score permanently. |
| 37 | Your lungs begin to grow, increasing the amount of time you can hold your breath. |
| 38 | Your teeth become soft and brittle, causing them to fall out when you eat. |
| 39 | Your bones begin to melt down, giving you a sickening liquid flexibility. You have the ability to flatten and extend your body. |
| 40 | Your eyes begin to glow as if there is a candle lit behind them. The light doesn't affect your vision, and it produces enough light to see a few feet in front of you. |
| 41 | Your skin becomes incredibly sensitive to sunlight. When in direct sunlight, you begin to take a small amount of damage every hour. |
| 42 | The bones in your face begin to painfully contort until your jaw twists into a makeshift beak. |
| 43 | A smooth, fleshy tail sprouts out of your back. |
| 44 | Your ears begin to grow 5 times their normal size. This allows you to hear things exceptionally far away. |
| 45 | Your brain seems to double in size, giving your head a disgusting bulging look. Add +1 to your intelligence score permanently. |
| 46 | Your fingers begin to fuse into groups until your hands begin to resemble flesh claws. |
| 47 | Your legs begin to grow and contort, until you grow an extra foot. |
| 48 | A very thick, dense fur grows all across your body, resembling a bear. |
| 49 | Your eyes begin to change color based on your mood. |
| 50 | A second face begins to grow in a random location on your body. This face has its own set of independent thoughts, but it looks and sounds exactly like your face. |
| 51 | Your neck begins to twist and shrink into your torso. Your head can now retract into your body on command. |
| 52 | You develop a massive underbite which causes you to drool uncontrollably. |
| 53 | Fleshy bat wings begin to sprout out of your back. |
| 54 | Your veins grow to be 3 times their normal size causing your arms and legs to bulge in a disgusting display. |
| 55 | You suddenly have the uncanny ability to regenerate lost limbs. Small appendages such as fingers take 1d4 hours to grow back, while an arm or a leg takes 1d4 days. |
| 56 | Your face begins to reshape and contort, leaving you with horrid flesh mandibles resembling that of a demonic insect. You can only speak in low, rhythmic chittering sounds now. |
| 57 | You grow a massive, puffed-out neck pouch that resembles a frog on your neck. |
| 58 | Your fingers grow a webbing between them. |
| 59 | Eyes begin to sprout all over your body. You can't be surprised in combat anymore but people are afraid of you. |
| 60 | You grow an additional 1d20 fingers on both of your hands. |
| 61 | Your skin becomes ghostly white and your eyes take on a red shine. |
| 62 | Hideous lumps begin to sprout all across your body. |
| 63 | Your fingers are replaced with wiggling tentacles covered in suckers. |
| 64 | A horrid rotting smell begins to emit from your skin. Your whole body turns a slight green color. |
| 65 | Your eyes begin to bulge out of your head and turn a milky white color. |
| 66 | For some reason, insects are attracted to you. Any and every insect in the area stops what it's doing and crawls, slithers, and creeps towards you. |
| 67 | Your feet twist and contort until they resemble hands. |
| 68 | Your nostrils begin to grow larger until they run together, leaving your nose a disgusting fleshy snout. |
| 69 | Flesh-colored mushrooms begin to sprout out of your skin. They can be harvested and brewed into a delicious tea. |
| 70 | Your head begins to expand, growing three times its normal size. |
| 71 | Your nose becomes large and bulbous, like a mushroom. |
| 72 | Your feet begin to bend and contort into hooves. |
| 73 | Shiny, fish-like scales begin to grow all across your body. |
| 74 | Your brain shrinks to half of its normal size, giving you a much lower intelligence. |
| 75 | Your eyes begin to bulge until they resemble the eyes of a chameleon. You can now look in two different directions. |
| 76 | Your back begins to twist and contort, revealing a massive hunchback forming on your back. The immense weight of the hunchback causes your spine to bend forward, giving you a hunched position. |
| 77 | Hundreds of small, sharp bone thorns break through your flesh and cover your body. Through the flexing of certain muscles, you are able to shoot the thorns at enemies who are nearby. |
| 78 | One of your arms begins to grow much longer than the other one. |
| 79 | You feel as though your thoughts are not entirely your own. You get the strangest feeling that there is another being presenting itself within your consciousness. |
| 80 | Your face begins to take on a sunken, gaunt appearance until it's difficult to tell the difference between you and a lich. |
| 81 | Your very blood becomes plagued with toxic and poisonous substances. Your blood can injure another being if it comes into contact. |
| 82 | Your eye sockets begin to twist and contort, growing away from your face. From now on, your eyes are attached to your face through flesh stalks. |
| 83 | Your skin becomes a faded blue color and a mystical pattern begins to present itself all across your body, like a light tattoo. When damaged by magical means, the damage inflicted upon you is reduced by 1d4. |
| 84 | Your eyelid skin suddenly fuses together, leaving you blind as a bat. Also like a bat, you can now rely on a new ability: echolocation. |
| 85 | Painful horns begin to grow out of the sides of your head, pushing through the skin. |
| 86 | You begin to form a membranous crest on the top of your head, like a reptile. All of the hair on your head falls out. |
| 87 | Your teeth become razor sharp and your saliva now secretes a minor poison. |
| 88 | Suddenly, whatever you are carrying in your hand at this exact moment fuses to your hand and is held in place permanently. Unless, of course, the hand is removed... |
| 89 | Horrible, discolored bumps begin to grow all across your body. During combat, they sometimes burst, filling the battle with a disgusting smell. |
| 90 | You begin to grow black and white feathers all over your body. |
| 91 | Your skin begins to take on a transparent look, allowing your innards to be seen. |
| 92 | Your nose twists and contorts into a pig-like snout. It has a keen sense of smell. |
| 93 | Large boils begin to cover your skin. When they pop, a swarm of flies crawls out of the wound. |
| 94 | Your eyes twist and turn until they are pointed in opposite directions. |
| 95 | One of your arms begins to twist and form a claw. The skin around the claw begins to harden over time until it resembles a crab claw. |
| 96 | Fingers begin to grow out of the top of your head like hair. |
| 97 | Your lower limbs become fused together to form a worm-like lower body. |
| 98 | Your tongue grows at a rapid rate and develops a barb at the end of it. It can now be used as a whip. |
| 99 | Small suckers appear all over your legs and arms, like an octopus. |
| 100 | One of your legs shrinks by a foot, giving you a severe limp when you walk. |